Clinical Evidence Supports the Comprehensive Potential of New Bellus NB® 23 in Supporting Muscle Strength, Metabolic Stability and Physical Function
Market Insight｜Rising Demand for Healthy Aging and Metabolic Support
As people age, maintaining mobility and metabolic balance becomes increasingly important. According to a report by Mordor Intelligence, the global probiotics market is projected to grow from USD 78.91 billion in 2024 to USD 113.43 billion by 2029, at a CAGR of 7.53%.
Meanwhile, global demographics point to an accelerating aging trend. The United Nations World Population Prospects 2024 estimates that the global population aged 65 and older will rise to approximately 2.2 billion by the late 2070s, at which point that age group will outnumber those under 18. This shift indicates that middle-aged and older adults will soon represent a large and rapidly growing segment of global consumers—and their demand for nutritional support for mobility, metabolic function, and quality of life is expected to rise accordingly.
Clinical Spotlight｜Lacticaseibacillus paracasei NB23 Shows Multi-Dimensional Health Potential
A newly published randomized, double-blind, placebo-controlled clinical trial in the international journal Probiotics and Antimicrobial Proteins investigated the impact of daily supplementation with Lacticaseibacillus paracasei NB23 over 12 weeks in healthy adults. Results highlighted several areas of improvement in metabolic and physical health indicators.
1. Supports Muscle Strength via IGF-1 Pathway Activation
Supplementation with Lacticaseibacillus paracasei NB23 led to elevated IGF-1 levels and activation of the PI3K/Akt/mTOR signaling pathway—key mechanisms in protein synthesis and muscle maintenance. This suggests Lacticaseibacillus paracasei NB23 may help sustain strength and mobility in aging populations.
2. Improves Metabolic and Circulatory Balance
Significant positive changes were observed in blood pressure, triglycerides, LDL/HDL ratios, and insulin resistance (HOMA-IR), supporting the role of Lacticaseibacillus paracasei NB23 in overall metabolic regulation.
3. Reduces Inflammatory Responses and Protein Breakdown Markers
After Lacticaseibacillus paracasei NB23 supplementation, levels of inflammatory markers IL-6 and TNF-α decreased significantly. Notably, IL-6, TNF-α, and PARP are all associated with cellular protein degradation pathways and serve as biomarkers for muscle catabolism and inflammatory stress. Their reduction suggests Lacticaseibacillus paracasei NB23 may help preserve protein balance and muscle integrity, contributing to overall physiological resilience.
Overall, Lacticaseibacillus paracasei NB23 demonstrated measurable benefits in supporting both metabolic health and muscle strength among healthy adults. Subjective feedback from participants also indicated improvements in physical condition, vitality, and daily performance.
Gentle, Science-Backed Support for Balanced Aging
New Bellus NB® 23 was designed with aging adults in mind—offering a scientifically supported, easy-to-use daily supplement to promote physical vitality and metabolic harmony. Whether for maintaining mobility or supporting metabolic wellness, New Bellus NB® 23 is a reliable companion for those pursuing a balanced, active lifestyle. This philosophy echoes the New Bellus brand vision: Be New, Be Beneficial, Be Limitless.
Small Things Creating Big Value
We believe true innovation starts with understanding user needs and building on proven science and advanced fermentation technology—allowing even the smallest probiotic strains to deliver meaningful impact.
New Bellus continues to lead in microbial fermentation innovation. With a strong foundation in functional probiotic development, New Bellus NB® 23 is a key result of our research platform, formulated to support everyday physiological resilience in aging populations.
References
1. Lin, S., Ko, W.S., Kuo, F.C., et al. (2025). The Effects of Lactobacillus paracasei NB23 on IGF-1, Muscle Function, and Cardiometabolic Risk Factors in Healthy Individuals: A Randomized Controlled Trial. Probiotics and Antimicrobial Proteins.
2. Mordor Intelligence Probiotics Market Report: https://www.mordorintelligence.com/zh-CN/industry-reports/probiotics-market
3. United Nations, Department of Economic and Social Affairs, Population Division. (2024). World Population Prospects 2024. https://population.un.org/wpp/